Nuclear magnetic resonance screening of multiple targets and the rational design of high-affinity ligands are now a main focus of drug discovery efforts. Adaptations of current NMR methods along with improvements to instrumentation are currently being developed as scientists implement high-throughput, automated approaches to accelerate the drug discovery process. Nuclear Magnetic Resonance explores end-users' satisfaction with industry innovations such as the integration of sophisticated radio frequency, improved digital electronics, automated probe/sample handling technologies and advanced bioinformatics. The investigation of end-user needs in Nuclear Magnetic Resonance can be leveraged across several product categories with the goals of developing better products and expanding market penetration. To this end, the survey data has been placed in context by cross-tabulating it with the responses to an initial 14-question survey designed to provide baseline data on the nature of the respondent's drug discovery research. Included in these cross-tabulations are: the stage of research, type of research, disease targets, biological processes studied, and other related products and services used regularly. The results of the seven surveys conducted for this unique series of reports clearly show that past distinctions between the stages of drug discovery are diminishing. Nuclear Magnetic Resonance is structured to reflect the market's integration, while highlighting end-user problems that represent exciting market opportunities for life science suppliers. Report Highlights Along with a comprehensive overview of significant findings, Nuclear Magnetic Resonance (NMR) contains detailed charts and graphs depicting the answers to all 33 survey questions and 20 cross-tabulations. Below is a glimpse of the key findings derived from just a few of the survey questions: • 46% of respondents participating in this survey conduct the majority of their lab's/group's NMR experiments in an on-site core facility or another lab/group in their company or institution. (Question 2)
• Respondents' report that "determining/confirming molecular structure" (87%) is the most frequently used NMR application in their lab/group. (Question 4)
• Overwhelmingly, 90% of respondents' labs are using high performance liquid chromatography (HPLC) in combination with NMR. (Question 11)
• 29% of respondents report that "inadequate concentration of sample" is the most significant performance limitation/operational problem that their lab experiences when performing NMR. (Question 20)
• Bruker Analytik (47%) was the company most frequently mentioned when the respondents were asked which company/supplier comes to mind when they think of NMR spectrometers. (Question 26) (electronic copy also includes 1 print copy)
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