Description

Nuclear magnetic resonance screening of multiple targets and the rational design of high-affinity ligands are now a main focus of drug discovery efforts. Adaptations of current NMR methods along with improvements to instrumentation are currently being developed as scientists implement high-throughput, automated approaches to accelerate the drug discovery process. Nuclear Magnetic Resonance explores end-users' satisfaction with industry innovations such as the integration of sophisticated radio frequency, improved digital electronics, automated probe/sample handling technologies and advanced bioinformatics. The investigation of end-user needs in Nuclear Magnetic Resonance can be leveraged across several product categories with the goals of developing better products and expanding market penetration. To this end, the survey data has been placed in context by cross-tabulating it with the responses to an initial 14-question survey designed to provide baseline data on the nature of the respondent's drug discovery research. Included in these cross-tabulations are: the stage of research, type of research, disease targets, biological processes studied, and other related products and services used regularly. The results of the seven surveys conducted for this unique series of reports clearly show that past distinctions between the stages of drug discovery are diminishing. Nuclear Magnetic Resonance is structured to reflect the market's integration, while highlighting end-user problems that represent exciting market opportunities for life science suppliers. Report Highlights Along with a comprehensive overview of significant findings, Nuclear Magnetic Resonance (NMR) contains detailed charts and graphs depicting the answers to all 33 survey questions and 20 cross-tabulations. Below is a glimpse of the key findings derived from just a few of the survey questions: • 46% of respondents participating in this survey conduct the majority of their lab's/group's NMR experiments in an on-site core facility or another lab/group in their company or institution. (Question 2) • Respondents' report that "determining/confirming molecular structure" (87%) is the most frequently used NMR application in their lab/group. (Question 4) • Overwhelmingly, 90% of respondents' labs are using high performance liquid chromatography (HPLC) in combination with NMR. (Question 11) • 29% of respondents report that "inadequate concentration of sample" is the most significant performance limitation/operational problem that their lab experiences when performing NMR. (Question 20) • Bruker Analytik (47%) was the company most frequently mentioned when the respondents were asked which company/supplier comes to mind when they think of NMR spectrometers. (Question 26) (electronic copy also includes 1 print copy)

Table of Contents

Section 1 Executive Overview & Introduction 1-1 Among the Study's Key Findings 1-2 History of the Technology 1-2 Applications and Usage 1-3 How NMR Spectroscopy Works 1-4 Technological Limitations and Safety Concerns 1-4 NMR Instrumentation Advances 1-5 Combined Technologies 1-6 Automation and the Future of NMR Technology Section 2 Study Methodology and Demographics 2-1 Objectives 2-1 Comments 2-2 Assumptions 2-3 Definition of Terms 2-4 Market Segment 2-4 Organization Size 2-4 Laboratory Size 2-4 Job Position 2-4 Geographic Region 2-5 Area(s) of Research Section 3 Significant Findings 3-1 Product Use & Application 3-2 Product Expectations 3-2 Technology & Suppliers Section 4 Presentation of Survey Data Product Use & Application 4-1 Current use of NMR 4-4 Location of NMR experiments 4-5 Principle reason why NMR experiments are not performed within own lab/group 4-7 Applications for which NMR is used 4-9 Type(s) of spectrometers used 4-11 Method(s) typically used to optimize NMR experimental results 4-12 Type(s) of spectra acquired in NMR experiments 4-13 Type(s) of NMR experiments typically conducted 4-14 Maximum radio frequency of the NMR spectrometer most typically used 4-16 Type(s) of protection against stray magnetic fields employed on the NMR spectrometer most commonly used 4-18 Techniques used in combination with NMR used 4-20 Emerging NMR technologies currently used 4-22 Number of samples run per month 4-24 Average number of different NMR experiments performed on a single sample 4-25 Future use of NMR 4-27 Application(s) for which NMR software is primarily used 4-28 Kinds of NMR software packages most commonly used Product Expectations 4-30 Most influential features in decision to use one NMR spectrometer over another 4-31 Most influential factor in decision to purchase one NMR spectrometer over another 4-33 Most significant performance limitation lab experiences when performing NMR 4-35 Most valuable improvement to conventional NMR technology 4-36 Most important characteristic in selecting one NMR software package over another 4-37 Most influential factor in decision to purchase one NMR spectrometer software over another 4-39 Interest in utilizing automated NMR sample preparation 4-41 Area the NMR industry should focus its product development efforts Technologies & Suppliers 4-42 "Top-of-mind" company/supplier for NMR spectrometers 4-43 Primary supplier for NMR spectrometers and related products and services 4-45 Familiarity with suppliers of NMR spectrometers and related products and services 4-47 Primary supplier of commercial NMR software packages 4-49 Familiarity with suppliers of commercial NMR software packages 4-51 Estimated percentage of current total annual budget for products/services dedicated to NMR applications 4-52 Estimated percentage of future total annual budget for products/services dedicated to NMR applications Section 5 Benchmarking Data 5-1 Stage of drug discovery research 5-2 Type of drug discovery research conducted 5-4 Disease focus of drug discovery research 5-6 Biological processes or states monitored 5-8 Techniques used 5-10 Automated systems used 5-12 Types of equipment used 5-13 "Top-of-mind" company for products and services for drug discovery Section 6 Appendices 6-1 Overall comments as to where suppliers should focus their efforts 6-2 Cross-Tabulations of Survey Data 6-22 Related Reports 6-28 About BioInformatics 6-29 Our Valued Clients